Decreased fetal movements : a sign of placental SARS-CoV-2 infection with perinatal brain injury
Favre, Guillaume; Mazzetti, Sara; Gengler, Carole; Bertelli, Claire; Schneider, Juliane; Laubscher, Bernard; Capoccia, Romina; Pakniyat, Fatemeh; Ben Jazia, Inès; Eggel-Hort, Béatrice; de Leval, Laurence; Pomar, Léo; Greub, Gilbert; Baud, David; Giannoni, Eric
2021

Résumé

Neonatal COVID-19 is rare and mainly results from postnatal transmission. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), however, can infect the placenta and compromise its function. We present two cases of decreased fetal movements and abnormal fetal heart rhythm 5 days after mild maternal COVID-19, requiring emergency caesarean section at 29 + 3 and 32 + 1 weeks of gestation, and leading to brain injury. Placental examination revealed extensive and multifocal chronic intervillositis, with intense cytoplasmic positivity for SARS-CoV-2 spike antibody and SARS-CoV-2 detection by RT-qPCR. Vertical transmission was confirmed in one case, and both neonates developed extensive cystic peri-ventricular leukomalacia.

Détails

Titre Decreased fetal movements : a sign of placental SARS-CoV-2 infection with perinatal brain injury
Auteur(s)/ trice(s) Favre, Guillaume (Materno-Fetal and Obstetrics Research Unit, Department Woman-Mother-Child, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland)
Mazzetti, Sara (Clinic of Pediatrics, Department Mother-Woman-Child, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland)
Gengler, Carole (Department of Laboratory Medicine and Pathology, Institute of Pathology, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland)
Bertelli, Claire (Institute of Microbiology, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland)
Schneider, Juliane (Clinic of Neonatology, Department Mother-Woman-Child, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland)
Laubscher, Bernard (Clinic of Pediatrics, Department Mother-Woman-Child, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland ; Department of Pediatrics, Réseau Hospitalier Neuchâtelois, Neuchâtel, Switzerland)
Capoccia, Romina (Department of Obstetrics and Gynecology, Réseau Hospitalier Neuchâtelois, Neuchatel, Switzerland)
Pakniyat, Fatemeh (Department of Obstetrics and Gynecology, Réseau Hospitalier Neuchâtelois, Neuchatel, Switzerland)
Ben Jazia, Inès (Department of Obstetrics and Gynecology, Réseau Hospitalier Neuchâtelois, Neuchatel, Switzerland)
Eggel-Hort, Béatrice (Department of Obstetrics and Gynecology, Hôpital du Valais—Centre Hospitalier du Valais Romand—Site de Sion, Sion, Switzerland)
de Leval, Laurence (Department of Laboratory Medicine and Pathology, Institute of Pathology, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland)
Pomar, Léo (Materno-Fetal and Obstetrics Research Unit, Department Woman-Mother-Child, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland ; HESAV School of Health Sciences, HES-SO University of Applied Sciences and Arts Western Switzerland)
Greub, Gilbert (Institute of Microbiology, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland ; Infectious Diseases Service, Department of Internal Medicine, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland)
Baud, David (Materno-Fetal and Obstetrics Research Unit, Department Woman-Mother-Child, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland)
Giannoni, Eric (Clinic of Neonatology, Department Mother-Woman-Child, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland)
Date 2021-12
Publié dans Viruses
Volume December 2021, vol. 12, no. 12, art. 2517
Pagination 11 p.
DOI https://doi.org/10.3390/v13122517
ISSN 1999-4915
Mots-clés (libres) SARS-CoV-2 ; COVID-19 ; perinatal ; placental ; brain injury ; fetal movements ; neurosonography ; MRI
Type d'article scientifique
Domaine Santé
Filière Sage-femme
Ecole HESAV
Institut Unité de recherche en santé, HESAV
Le document apparaît dans Articles scientifiques
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