Review objectives: The aim of this umbrella review is to identify and describe factors influencing diabetes self-management (DSM) in adults with diabetes. More specifically, we will address DSM-related factors and their relationships, considering both qualitative and quantitative components of available literature. The review question for the qualitative component of the umbrella review is: Which are the factors which act as barriers to, or facilitators of, DSM among adults with diabetes? The review questions for the quantitative component of the umbrella review are: What are the factors associated with DSM of adults with diabetes?What is the association between the identified factors and DSM in terms of strength and direction? An additional question will be applied to both the qualitative and quantitative components of the overview.