The visual accommodation is a complex biomechanical & optical process. Today in vivo imaging technologies do not allow to measure the eye components material propertiessuch asthe refractive index or the stiffness: these properties are essential to understand & diagnose the effect of aging on the eye accommodative performance and develop new surgeries. To address this problem, Kejako has set up a parametric 3D mechanical model of the human eye, in addition with an optical evaluation. This paper present how this model can be used to deduce with reverse engineering some of these non-measurable properties from in vivo imaging such as the refractive index distribution in the Crystalline Lens. Furthermore, we will open the discussion on some potential application of this model for Presbyopia or other eye disorders.