The scene of the computational sciences has considerably changed during the last years. Today, new emerging Desktop grid and Cloud e-infrastructure have a considerable potential to be adopted and used in large scale to exploit thousands of CPUs power to run both scientific and commercial applications. This paper targets scientists and programmers who need to accelerate their scientific research by running their applications on distributed Grid/Cloud infrastructures. We present a hybrid Grid/Cloud platform used to deploy a phylogeny application called MetaPIGA. The aim is to combine the advantages of Grid and Cloud architectures in order to set up a robust, reliable and open platform. We propose two scenarios.