Welcome to the 10th ACM/IEEE International Conference on Cyber-Physical Systems, part of the 2019 CPS-IoT Week in Montreal, Canada. In the previous decade, ACM/IEEE ICCPS successfully established itself as the premier conference for reporting advances in all aspects of cyber-physical systems (CPS), including theory, tools, applications, systems, test-beds and field deployments. As in all previous years, ICCPS is held in conjunction with other conferences at CPS-IoT Week: HSCC, IPSN, RTAS, and IoTDI. This year, we have assembled a strong and diverse technical program containing papers on both theoretical advances and innovative applications in CPS. Theoretical papers cover range of topics including CPS security, design and analysis of CPS, wireless CPS, and learning for CPS. Covered application domains include water distribution networks, medical devices, wearables, smart grid, mobile devices/IoT, smart transportation, and smart cities. ICCPS 2019 also includes a WIP/Demo session that highlights new innovations and research in a poster presentation format.