The School of Management Fribourg (HEG-FR), member of the University of Applied Sciences and Arts Western Switzerland (HES-SO), in collaboration with SUPSI Manno in Switzerland, collected data for the international Global Entrepreneurship Monitor (GEM). 2448 telephone interviews and 36 talks with experts revealed entrepreneurial attitudes, activities and aspirations, and identified the factors infl uencing the type and extent of the entrepreneurial activities. The 2018 / 2019 Global Entrepreneurship Monitor Report on Switzerland illustrates national differences in entrepreneurial activity between economies, revealing the factors that determine the nature and level of national entrepreneurial activity, and identifying policy implications for enhancing entrepreneurship in Switzerland.