This paper introduces Perplexus, a European project that aims to develop a scalable hardware platform made of custom reconfigurable devices endowed with bio-inspired capabilities. This platform will enable the simulation of large-scale complex systems and the study of emergent complex behaviors in a virtually unbounded wireless network of computing modules. The final infrastructure will be used as a simulation tool for three applications: neurobiological modeling, culture dissemination modeling, and cooperative collective robotics. The Perplexus platform will provide a novel modeling framework thanks to the pervasive nature of the hardware platform, its bio-inspired capabilities, its strong interaction with the environment, and its dynamic topology.