We present an overview of IMPACT, a system that uses virtual and augmented reality to enhance the mirror therapy for the treatment of phantom limb pain and stroke rehabilitation. The system tracks users’ movements and the head position using a combination of depth cameras and inertial sensors. This information is then fused together in a 3D full-body human model able to adapt to the patient’s characteristics (e.g., skin color, limb size) and avoid unnatural movements due to possible bad tracking (e.g., a joint bended in an unnatural way). IMPACT includes three serious games that can be played in first-person point of view and that allow different levels of immersion according to the needs of the treatment.