Medical experts commonly use imaging including Computed Tomography (CT), Positron-Emission Tomography (PET) and Magnetic Resonance Imaging (MRI) for diagnosis or to plan a surgery. These scans give a highly detailed representation of the patient anatomy, but the usual Three-Dimensional (3D) separate visualisations on screens does not provide an convenient and performant understanding of the real anatom-ical complexity. This paper presents a computer architecture allowing medical staff to visualise and interact in real-time holographic fused CT, PET, MRI of patients. A dedicated workstation with a wireless connec-tion enables real-time General-Purpose Processing on Graphics Process-ing Units (GPGPU) ray casting computation through the mixed reality (MR) headset. The hologram can be manipulated with hand gestures and voice commands through the following interaction features: instan-taneous visualisation and manipulation of 3D scans with a frame rate of 30 fps and a delay lower than 120 ms. These performances give a seamless interactive experience for the user.