Institutes of higher education can no longer pretend that the Fourth Industrial Revolution will not impact the way that learning is viewed, and education delivered. This article looks at changes in education from the perspective of students, educators, administrators complemented by practitioner action research in the classroom. In answer to the question of how to induce 21st century change in higher education, a meta-interpretation (Weed, 2005) of six related research studies carried out over the period 2014‒2017 was conducted. This in turn has allowed for a comprehensive analysis and the identification of key change-related findings that cut across the afore-mentioned stakeholder groups. A framework for change is put forth for administrators and examples for innovative classroom practice are provided for educators.