The increasing mobility of populations strongly affects the development of territories. Indeed, mobility for studies, hobbies, vacations, retirement as well as commuting (professional and of students) and multi-residency (second homes) have raised in recent years. As a result, the effects of this evolution are no longer limited to production (exports of goods and services), but also more and more to consumption. Two recent approaches, the residential economy and the presential (face-to-face) economy (Davezies 2008; Terrier 2009), account for these phenomena and show that the most prosperous regions are not necessarily the most economically productive (Segessemann and Crevoisier 2015; Jousseaume and Talandier 2016). Capturing income streams and generating the expense can be just as important to a region as its performance in producing export-oriented goods and services. What is the current situation of the Swiss regions in relation to these three modes of development? In this context, the comprehension of the spatial articulation of production and consumption within the framework of an integrated “productive, presential and residential system” (PPRS) becomes an important issue. Following Davezies and Talandier (2014), this paper has two main objectives: based on a quantitative approach, the first is to identify productive and presential supply-side activities, and their articulation with local demand of residents in Switzerland. The second objective is the identification of interdependencies between these two systems of supply and demand, in order to contribute to the redefinition of spatial planning and spatial impact policies for regional development.