The use of green solvents is a key element in making chemical processes more sustainable. In this work, three biobased solvents, diformyl xylose (DFX), dipropyl xylose (DPX), and n-butyl tetrahydrofurfuryl ether (Solvinol), were tested as cosolvents in the Suzuki–Miyaura reaction using micellar catalysis in water (TPGS-750-M system). 2% DPX gave > 99% conversion and 86% yield, while 2% DFX reached 86% conversion and 82% yield. Solvinol required 15% loading to give similar results. DFX was easily removed in the aqueous phase upon work-up, while DPX and Solvinol were more difficult to remove due to their poor water solubility and high boiling points. These results demonstrate the potential of biomass-derived solvents as green alternatives to classical organic solvents. The overall environmental efficiency of the various processes was assessed via our internal methodology. Their efficiency at low loadings supports their use in more sustainable and environmentally friendly processes.
