Résumé

This paper proposes a novel imaging biomarker of lung cancer relapse from 3–D texture analysis of CT images. Three–dimensional morphological nodular tissue properties are described in terms of 3–D Riesz–wavelets. The responses of the latter are aggregated within nodular regions by means of feature covariances, which leverage rich intra– and inter– variations of the feature space dimensions. When compared to the classical use of the average for feature aggregation, feature covariances preserve spatial co–variations between features. The obtained Riesz–covariance descriptors lie on a manifold governed by Riemannian geometry allowing geodesic measurements and differentiations. The latter property is incorporated both into a kernel for support vector machines (SVM) and a manifold–aware sparse regularized classifier. The effectiveness of the presented models is evaluated on a dataset of 110 patients with non–small cell lung carcinoma (NSCLC) and cancer recurrence information. Disease recurrence within a timeframe of 12 months could be predicted with an accuracy of 81.3–82.7%. The anatomical location of recurrence could be discriminated between local, regional and distant failure with an accuracy of 78.3–93.3%. The obtained results open novel research perspectives by revealing the importance of the nodular regions used to build the predictive models.

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