Purpose : The impact of digital technology in the wider travel field has been substantial and significant, changing both the competitive landscape of businesses and the behavior of travelers. However, we are now on the cusp of new digital developments encompassing cloud computing, blockchain, internet of things (IoT) and above all, artificial intelligence (AI), which are predicted to disrupt the business and consumer sides of several industries – travel included. This study aims to frame this upcoming digital transformation in travel within a human-centered approach where the critical understanding of digital humanism principles will enrich social scientists’ research agenda in the coming years. Design/methodology/approach : The viewpoint follows a structure based on (i) setting the scene for the rise of digital transformation, (ii) the historical perspective on digital transformation in travel, (iii) the pandemic’s impact and (iv) future development and research agenda. Findings : It is only by fostering a human-centered digital transformation perspective that social science researchers in travel can realize the “high-tech for high-touch” promise of fostering a human-to-human encounter empowered and possibly hampered, by digital technologies. This work proposes to start from the concepts of digital technology control, participation, education and ethics to design a research agenda with a 2050 horizon. Originality/value : This work has been designed to shift the attention of researchers toward a human-centered digital transformation approach to reflect on the human-machine relationship for a better society. Due to its inner characteristics the travel field can foster a reflection on this topic by reaffirming the centrality of human beings and their authorship in the travel product creation.