TY - GEN AB - Objective: Winter birth has consistently been identified as a risk factor for schizophrenia. This study aimed to determine whether individuals born during this season are also at higher risk for early psychosis and whether this is associated with distinct functional and clinical outcomes. Methods: We conducted a prospective study on 222 patients during their early phase of psychosis in Switzerland, nested in the Treatment and Early Intervention in Psychosis (TIPP) cohort. We compared the birth trimesters of these patients with those of the general Swiss population. Additionally, we evaluated the Global Assessment of Functioning scale (GAF) and the Positive and Negative Syndrome Scale (PANSS) scores among patients born in winter (January to March) versus those born during the rest of the year during a three-year follow-up period. Results: A significantly higher proportion of patients experiencing early psychosis were born in winter compared to the general Swiss population. Patients born in winter had significantly lower GAF scores at 6 months, 24 months, and 36 months of follow-up, compared to patients born during the rest of the year. They also manifested fewer positive symptoms, as indicated by the PANSS positive subscale. Conclusion: Birth in winter appears to be associated with a lower functional outcome and potentially distinct symptomatology in the early phase of psychosis AD - Service of General Psychiatry, Department of Psychiatry, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland; Center for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland; Service of Emergency Medicine, Department of Acute Medicine, Geneva University Hospitals, Geneva, Switzerland AD - Service of General Psychiatry, Department of Psychiatry, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland; La Source School of Nursing, HES-SO, Lausanne AD - Center for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland AD - Service of General Psychiatry, Department of Psychiatry, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland AD - Service of General Psychiatry, Department of Psychiatry, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland; Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College of London, London, UK; Centro Investigacion Biomedica en Red de Salud Mental (CIBERSAM), Instituto de Biomedicina de Sevilla (IBIS), Hospital Universitario Virgen del Rocio, Departamento de Psiquiatria, Universidad de Sevilla, Sevilla, Spain AD - Center for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland AD - Center for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland AD - Service of General Psychiatry, Department of Psychiatry, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland AD - Service of General Psychiatry, Department of Psychiatry, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland AD - Center for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland AD - Service of General Psychiatry, Department of Psychiatry, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland AD - Center for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland AD - Center for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland; Service of Child and Adolescent Psychiatry, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland AU - Restellini, Romeo AU - Golay, Philippe AU - Jenni, Raoul AU - Baumann, Philipp S. AU - Alameda, Luis AU - Allgäuer, Larissa AU - Steullet, Pascal AU - Abrahamyan Empson, Lilith AU - Mebdouhi, Nadir AU - Quang Do, Kim AU - Conus, Philippe AU - Dwir, Daniella AU - Klauser, Paul CY - - DA - 2024-12 DO - 10.1016/j.schres.2024.09.022 DO - DOI EP - 206-211 ID - 14814 JF - Schizophrenia Research KW - Santé KW - schizophrenia KW - season of birth KW - TIPP KW - psychosis KW - functional outcome KW - winter birth L1 - https://arodes.hes-so.ch/record/14814/files/RestelliniEtal_2024_Winter_birth.pdf L2 - https://arodes.hes-so.ch/record/14814/files/RestelliniEtal_2024_Winter_birth.pdf L4 - https://arodes.hes-so.ch/record/14814/files/RestelliniEtal_2024_Winter_birth.pdf LA - eng LK - https://arodes.hes-so.ch/record/14814/files/RestelliniEtal_2024_Winter_birth.pdf N2 - Objective: Winter birth has consistently been identified as a risk factor for schizophrenia. This study aimed to determine whether individuals born during this season are also at higher risk for early psychosis and whether this is associated with distinct functional and clinical outcomes. Methods: We conducted a prospective study on 222 patients during their early phase of psychosis in Switzerland, nested in the Treatment and Early Intervention in Psychosis (TIPP) cohort. We compared the birth trimesters of these patients with those of the general Swiss population. Additionally, we evaluated the Global Assessment of Functioning scale (GAF) and the Positive and Negative Syndrome Scale (PANSS) scores among patients born in winter (January to March) versus those born during the rest of the year during a three-year follow-up period. Results: A significantly higher proportion of patients experiencing early psychosis were born in winter compared to the general Swiss population. Patients born in winter had significantly lower GAF scores at 6 months, 24 months, and 36 months of follow-up, compared to patients born during the rest of the year. They also manifested fewer positive symptoms, as indicated by the PANSS positive subscale. Conclusion: Birth in winter appears to be associated with a lower functional outcome and potentially distinct symptomatology in the early phase of psychosis PB - Elsevier PP - - PY - 2024-12 SN - 09209964 SP - 206-211 T1 - Winter birth :a factor of poor functional outcome in a Swiss early psychosis cohort TI - Winter birth :a factor of poor functional outcome in a Swiss early psychosis cohort UR - https://arodes.hes-so.ch/record/14814/files/RestelliniEtal_2024_Winter_birth.pdf VL - 274 Y1 - 2024-12 ER -