@article{Restellini:14814,
      recid = {14814},
      author = {Restellini, Romeo and Golay, Philippe and Jenni, Raoul and  Baumann, Philipp S. and Alameda, Luis and Allgäuer, Larissa  and Steullet, Pascal and Abrahamyan Empson, Lilith and  Mebdouhi, Nadir and Quang Do, Kim and Conus, Philippe and  Dwir, Daniella and Klauser, Paul},
      title = {Winter birth : a factor of poor functional outcome in a  Swiss early psychosis cohort},
      publisher = {Elsevier},
      journal = {Schizophrenia Research},
      address = {-. 2024-12},
      number = {ARTICLE},
      pages = {6 p.},
      abstract = {Objective: Winter birth has consistently been identified  as a risk factor for schizophrenia. This study aimed to  
determine whether individuals born during this season are  also at higher risk for early psychosis and whether this is  associated with distinct functional and clinical  outcomes.
Methods: We conducted a prospective study on 222  patients during their early phase of psychosis in  Switzerland, nested in the Treatment and Early Intervention  in Psychosis (TIPP) cohort. We compared the birth  trimesters of these patients with those of the general  Swiss population. Additionally, we evaluated the Global  Assessment of Functioning scale (GAF) and the Positive and  Negative Syndrome Scale (PANSS) scores among patients born  in winter (January to March) versus those born during the  rest of the year during a three-year follow-up  period.
Results: A significantly higher proportion of  patients experiencing early psychosis were born in winter  compared to the general Swiss population. Patients born in  winter had significantly lower GAF scores at 6 months, 24  months, and 36 months of follow-up, compared to patients  born during the rest of the year. They also manifested  fewer positive symptoms, as indicated by the PANSS positive  subscale.
Conclusion: Birth in winter appears to be  associated with a lower functional outcome and potentially  distinct 
symptomatology in the early phase of psychosis},
      url = {http://arodes.hes-so.ch/record/14814},
      doi = {https://doi.org/10.1016/j.schres.2024.09.022},
}