In all health professions the use of serious games and VR simulation for training is increasingly adopted. Indeed, recent literature demonstrates the added value of immersive simulations to learn and improve the skills of health care professionals as well as their contribution to improving the quality of care, increasing patient safety, and minimizing the costs of training programs. In this project, we developed a simulation-based serious game allowing students and professionals to practice on the evaluation of the patients’ state of consciousness according to the Glasgow scale.