There is mounting interest on all aspects related to management innovation, as evidence shows firms relying on this source of innovation are better set to cope with market competition. HRM function is deemed to play a fundamental role in securing innovative organizational activities. Yet, much research is needed to disentangle the relationship between the HRM function and this source of innovation. We contend that manufacturing firms differ in innovation intensity and HRM role in pursuing innovation activities. Drawing on original survey data from three disparate manufacturing industries, chemical, renewable energy and biotechnology, this work analyzes the relationship between HRM practices and management innovation activities, and the effect that these interplay has on the firm’s innovation. Finally, the paper presents the conclusions obtained, the limitations of the study and future lines of research.