The evolution of distribution channels in the hospitality industry has followed diverse paths over time depending on the technology used. Distribution channels can be clustered into three generations, starting with the pre-WWW era; the middle generation comprising Internet-based direct booking channels and the latest generation including online intermediaries. This research focuses on the comparison of rates of adoption across different generations of distribution channels in the Swiss hotel sector taking into account substitution effects. Data for the study are a series of annual surveys (2002–2013) monitoring the evolution of market shares of 15 individual distribution channels. The objective of this research is the analysis of the evolution of market shares of different generations using multi-generation diffusion methods. Results suggest that decaying traditional and web-based direct channels have low or inexistent imitation effect. This research adds the explanation of mixed effects (innovation and imitation) across generations in the adoption processes.